A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

Author:

Han Jingyan12,Zhang Guoying1,Welch Emily J.2,Liang Ying3,Fu Jian4,Vogel Stephen M.25,Lowell Clifford A.6,Du Xiaoping2,Cheresh David A.7,Malik Asrar B.25,Li Zhenyu1

Affiliation:

1. Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY;

2. Department of Pharmacology, University of Illinois, Chicago, IL;

3. Division of Hematology and Bone Marrow Transplantation, Department of Internal Medicine, and

4. Graduate Center for Toxicology, University of Kentucky, Lexington, KY;

5. Center for Lung and Vascular Biology, University of Illinois, Chicago, IL;

6. Department of Laboratory Medicine, University of California, San Francisco, CA; and

7. Department of Pathology, Moores University of California San Diego Cancer Center, La Jolla, CA

Abstract

Key Points In contrast to c-Src and Yes, Lyn stabilizes endothelial junctions through interaction and phosphorylation of FAK.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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