Visualization of nitric oxide production by individual platelets during adhesion in flowing blood-Reference-Cited by-同舟云学术

Visualization of nitric oxide production by individual platelets during adhesion in flowing blood

Published:2015-01-22 Issue:4 Volume:125 Page:697-705
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cozzi Maria Rita¹,Guglielmini Giuseppe²,Battiston Monica¹,Momi Stefania²,Lombardi Elisabetta¹,Miller Edward Cole¹,De Zanet Denise¹,Mazzucato Mario¹,Gresele Paolo²,De Marco Luigi¹³

Affiliation:

1. Department of Translational Research, Stem Cells Unit, Centro di Riferimento Oncologico-IRCCS, National Cancer Institute, Aviano, Italy;

2. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; and

3. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

Abstract

Key Points The production of NO by platelets and its possible role are controversial. We visualize NO formed by single platelets adhering to collagen under flow conditions and show that it depends on Ca++ and modulates adhesion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/4/697/1387219/697.pdf

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5. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase.;Fleming;Am J Physiol Regul Integr Comp Physiol,2003

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