Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia-Reference-Cited by-同舟云学术

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia

Published:2017-05-25 Issue:21 Volume:129 Page:2908-2916
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zaimoku Yoshitaka¹²,Takamatsu Hiroyuki¹,Hosomichi Kazuyoshi³,Ozawa Tatsuhiko⁴,Nakagawa Noriharu¹,Imi Tatsuya¹,Maruyama Hiroyuki¹,Katagiri Takamasa⁵,Kishi Hiroyuki⁴,Tajima Atsushi³,Muraguchi Atsushi⁴,Kashiwase Koichi⁶,Nakao Shinji¹

Affiliation:

1. Department of Hematology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan;

2. Department of Internal Medicine, Keiju Medical Center, Nanao, Japan;

3. Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan;

4. Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan;

5. Clinical Laboratory Science, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; and

6. Department of HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan

Abstract

Key Points Somatic mutations of HLA-B*40:02 are very frequently detected in granulocyte of patients with acquired aplastic anemia. Antigen presentation via HLA-B4002 may play a critical role in the pathophysiology of acquired aplastic anemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/21/2908/1401670/blood752378.pdf

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