Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia-Reference-Cited by-同舟云学术

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

Published:2013-07-04 Issue:1 Volume:122 Page:100-108
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Krönke Jan¹,Bullinger Lars¹,Teleanu Veronica¹,Tschürtz Florian¹,Gaidzik Verena I.¹,Kühn Michael W. M.¹,Rücker Frank G.¹,Holzmann Karlheinz²,Paschka Peter¹,Kapp-Schwörer Silke¹,Späth Daniela¹,Kindler Thomas³,Schittenhelm Marcus⁴,Krauter Jürgen⁵,Ganser Arnold⁵,Göhring Gudrun⁶,Schlegelberger Brigitte⁶,Schlenk Richard F.¹,Döhner Hartmut¹,Döhner Konstanze¹

Affiliation:

1. Department of Internal Medicine III, and

2. Interdisciplinary Center for Clinical Research, Genomics Core Facility, University of Ulm, Ulm, Germany;

3. University Medical Center, Johannes Gutenberg University, Mainz, Germany;

4. Department of Hematology/Oncology, Eberhard Karls University, Tübingen, Germany; and

5. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, and

6. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

Abstract

Key Points Relapsed AML with NPM1 mutation is genetically related to the primary leukemia and characterized by an increase in high-risk aberrations. DNMT3A mutations show the highest stability and thus may precede NPM1 mutations.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/1/100/1368886/100.pdf

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