Autoimmune and other acquired neutropenias

Author:

Newburger Peter E.1

Affiliation:

1. Departments of Pediatrics and Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Abstract

Abstract This educational review addresses the diagnostic evaluation of patients for autoimmune and other forms of acquired neutropenia, including the futility of deconstructing the overlap of chronic “autoimmune,” “benign,” and “idiopathic” categories. Isolated neutropenias caused by infection, drugs, and immunologic disorders are also addressed. Discussion of management options emphasizes a conservative approach, with largely supportive care for these mostly benign and self-limited disorders.

Publisher

American Society of Hematology

Subject

Hematology

Reference36 articles.

1. Phagocyte system and disorders of granulopoiesis and granulocyte function;Dinauer,2015

2. Evaluation and management of patients with isolated neutropenia;Newburger;Semin Hematol,2013

3. Children with rare diseases of neutrophil granulocytes - from therapeutic orphans to pioneers of individualized therapies;Klein;Hematology Am Soc Hematol Educ Program,2016

4. Aplastic anemia and clonal evolution: Germ line and somatic genetics;Shimamura;Hematology Am Soc Hematol Educ Program,2016

5. Primary autoimmune neutropenia in children: a study of neutrophil antibodies and clinical course;Bruin;Vox Sang,2005

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