Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

Author:

Lindahl Lise M.1,Willerslev-Olsen Andreas2,Gjerdrum Lise M. R.3ORCID,Nielsen Pia R.3ORCID,Blümel Edda2ORCID,Rittig Anne H.1ORCID,Celis Pamela4,Herpers Bjorn5,Becker Jürgen C.6ORCID,Stausbøl-Grøn Birgitte1,Wasik Mariusz A.7,Gluud Maria2,Fredholm Simon2,Buus Terkild B.2ORCID,Johansen Claus1,Nastasi Claudia2,Peiffer Lukas6,Kubat Linda6,Bzorek Michael3,Eriksen Jens O.3,Krejsgaard Thorbjørn2,Bonefeld Charlotte M.2,Geisler Carsten2ORCID,Mustelin Tomas8,Langhoff Erik9,Givskov Michael10,Woetmann Anders2ORCID,Kilian Mogens11ORCID,Litman Thomas2ORCID,Iversen Lars1,Odum Niels2ORCID

Affiliation:

1. Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark;

2. LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark;

3. Department of Pathology, Zealand University Hospital, Roskilde, Denmark;

4. Department of Molecular Medicine, Aarhus University, Aarhus, Denmark;

5. Regional Public Health Laboratory Kennemerland, Haarlem, The Netherlands;

6. Department of Translational Skin Cancer Research, German Cancer Consortium, Dermatology, University Hospital of Essen, Essen, Germany;

7. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA;

8. Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA;

9. James J. Peters VA Medical Center, Veterans Affairs, Bronx, New York, NY; and

10. Costerton Biofilm Center, University of Copenhagen, Copenhagen, Denmark

11. Department of Biomedicine, Aarhus University, Aarhus, Denmark;

Abstract

Abstract This paper reports that aggressive antibiotic treatment inhibits disease activity and lymphocyte proliferation in cutaneous T-cell lymphoma (CTCL). The study offers important evidence for a link between bacterial infection, activation of the immune system, and CTCL progression.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference38 articles.

1. The pathogenesis of mycosis fungoides;Girardi;N Engl J Med,2004

2. Malignant inflammation in cutaneous T-cell lymphoma-a hostile takeover;Krejsgaard;Semin Immunopathol,2017

3. Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma. [published online ahead of print January 10, 2019];Vieyra-Garcia;JCI Insight,2019

4. In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3;Sommer;Leukemia,2004

5. Advanced-stage Mycosis fungoides. Role of STAT3, NFKB and NFAT pathways. [published online ahead of print 3 May 2019];Pérez;Br J Dermatol

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