circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression-Reference-Cited by-同舟云学术

circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression

Published:2019-08-06 Issue:18 Volume:134 Page:1533-1546
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sun Yu-Meng¹,Wang Wen-Tao¹,Zeng Zhan-Cheng¹,Chen Tian-Qi¹,Han Cai¹,Pan Qi¹,Huang Wei¹,Fang Ke¹,Sun Lin-Yu¹,Zhou Yan-Fei¹,Luo Xue-Qun²,Luo Chengwei³,Du Xin³,Chen Yue-Qin¹

Affiliation:

1. MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou, China;

2. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; and

3. Department of Hematology, Guangdong Provincial People’s Hospital, Guangzhou, China

Abstract

Sun et al identify a circular RNA, circMYBL2, that upregulates FLT3 translation to promote FLT3-ITD acute myeloid leukemia (AML) progression, suggesting a novel therapeutic target for FLT3-ITD AML.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/18/1533/1504094/bloodbld2019000802.pdf

Reference58 articles.

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4. Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications;Takahashi;J Hematol Oncol,2011

5. FLT3-TKD mutation in childhood acute myeloid leukemia;Liang;Leukemia,2003

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