A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib-Reference-Cited by-同舟云学术

A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib

Published:2019-12-19 Issue:25 Volume:134 Page:2271-2280
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Manwani Richa¹,Cohen Oliver¹,Sharpley Faye¹,Mahmood Shameem¹,Sachchithanantham Sajitha¹,Foard Darren¹,Lachmann Helen J.¹,Quarta Cristina¹,Fontana Marianna¹,Gillmore Julian D.¹,Whelan Carol¹,Hawkins Philip N.¹,Wechalekar Ashutosh D.¹

Affiliation:

1. National Amyloidosis Centre, University College London, Royal Free Campus, London, United Kingdom

Abstract

This article reports the largest series of patients with systemic AL amyloidosis to date treated with first-line bortezomib. With relatively mature follow-up, the data indicate the importance of a stringent dFLC response (difference in involved and uninvolved light chains) as a predictor of prolonged response.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/25/2271/1549293/bloodbld2019000834.pdf

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