Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice-Reference-Cited by-同舟云学术

Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice

Published:2019-08-06 Issue:16 Volume:134 Page:1312-1322
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lee Seungwon¹^ORCID,Kim Hyekang¹,You Gihoon¹,Kim Young-Min²,Lee Seunghun³,Le Viet-Hoan¹^ORCID,Kwon Ohseop¹,Im Sin-Hyeog¹²⁴^ORCID,Kim You-Me¹²,Kim Kwang Soon¹⁴^ORCID,Sung Young Chul¹²,Kim Ki Hean¹³,Surh Charles D.¹²⁴⁵,Park Yunji¹^ORCID,Lee Seung-Woo¹²^ORCID

Affiliation:

1. Division of Integrative Biosciences and Biotechnology,

2. Department of Life Sciences, and

3. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea;

4. Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea; and

5. Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA

Abstract

Abstract Lee and colleagues investigated the role of the intestinal microbiota in steady-state hematopoieisis, demonstrating that microbiota-derived DNA circulates to the bone marrow, where uptake by mononuclear cells leads to inflammatory cytokine production favoring myeloid-cell maturation of hematopoietic progenitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/16/1312/1248548/bloodbld2019000495.pdf

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