T-cell–redirecting bispecific antibodies in multiple myeloma: a revolution?-Reference-Cited by-同舟云学术

T-cell–redirecting bispecific antibodies in multiple myeloma: a revolution?

Published:2022-06-30 Issue:26 Volume:139 Page:3681-3687
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Moreau Philippe¹²,Touzeau Cyrille¹²

Affiliation:

1. 1Department of Hematology, University Hospital Hôtel-Dieu, Nantes, France; and

2. 2Nantes Université, INSERM, CRCI2NA, Nantes, France

Abstract

Abstract Bispecific antibodies are monoclonal antibodies targeting both a surface molecule on the malignant plasma cells and CD3 on T cells, leading to tumor cell death by activated T cells. Bispecific antibodies targeting B-cell maturation antigen, GPRC5D or FcRH5, demonstrated promising efficacy with favorable safety profile in patients with triple-class refractory multiple myeloma. This novel immunotherapeutic modality will likely change the treatment paradigm in the coming years.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/139/26/3681/1904521/bloodbld2021014611c.pdf

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