Reevaluation of excessive erythrocytosis in diagnosing chronic mountain sickness in men from the world’s highest city-Reference-Cited by-同舟云学术

Reevaluation of excessive erythrocytosis in diagnosing chronic mountain sickness in men from the world’s highest city

Published:2020-10-15 Issue:16 Volume:136 Page:1884-1888
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Oberholzer Laura¹^ORCID,Lundby Carsten¹²^ORCID,Stauffer Emeric³⁴,Ulliel-Roche Mathilde⁵,Hancco Ivan⁵^ORCID,Pichon Aurélien⁶^ORCID,Lundby Anne-Kristine Meinild¹,Villafuerte Francisco C.⁷^ORCID,Verges Samuel⁵^ORCID,Robach Paul⁵⁸^ORCID

Affiliation:

1. Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;

2. Innland Norway University of Applied Sciences, Lillehammer, Norway;

3. Laboratoire Interuniversitaire de Biologie de la Motricité EA7424, Team “Vascular Biology and Red Blood Cell,” Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France;

4. Centre de Médecine du Sommeil et des Maladies Respiratoires, Hôpital Croix Rousse, Hospices Civils de Lyon, Lyon, France;

5. HP2 Laboratory, University Grenoble Alpes, INSERM, CHU Grenoble Alpes, Grenoble, France;

6. Laboratory Mobility, Aging & Exercise-EA 6314, Faculty of Sport Sciences, University of Poitiers, Poitiers, France;

7. Laboratorio de Fisiologia Comparada, Departamento de Ciencias Biologicas y Fisiologicas, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru; and

8. National School for Mountain Sports, Site of the National School for Skiing and Mountaineering, Chamonix, France

Abstract

The diagnosis of chronic mountain sickness (CMS) is based on a score including 7 clinical features (breathlessness, sleep disturbance, cyanosis, venous dilatation, paresthesia, headache, and tinnitus) in the setting of extreme erythrocytosis. Examining individuals in La Rinconada, Peru, the highest city in the world, the authors demonstrated that CMS at extreme altitude is not linked to elevation of hemoglobin, since CMS+ and CMS− individuals had similar levels of erythrocytosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/136/16/1884/1761209/bloodbld2019004508.pdf

Reference23 articles.

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3. High altitude disease;Monge;Arch Intern Med (Chic),1937

4. Chronic mountain sickness: clinical aspects, etiology, management, and treatment;Villafuerte;High Alt Med Biol,2016

5. Some clinical aspects of life at high altitudes;Hurtado;Ann Intern Med,1960

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