Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade-Reference-Cited by-同舟云学术

Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade

Published:2019-12-26 Issue:26 Volume:134 Page:2369-2382
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chapuy Bjoern¹²^ORCID,Stewart Chip³^ORCID,Dunford Andrew J.³^ORCID,Kim Jaegil³,Wienand Kirsty¹^ORCID,Kamburov Atanas³,Griffin Gabriel K.⁴,Chen Pei-Hsuan⁴,Lako Ana⁴,Redd Robert A.⁵^ORCID,Cote Claire M.¹,Ducar Matthew D.⁶,Thorner Aaron R.⁶,Rodig Scott J.⁴^ORCID,Getz Gad³⁷⁸^ORCID,Shipp Margaret A.¹^ORCID

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Department of Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany;

3. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA;

4. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;

5. Department of Data Sciences and

6. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA; and

7. Department of Pathology and

8. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Abstract

A deep dive into genomic aberrations in 37 new diagnoses of primary mediastinal B-cell lymphoma (PMBL) reveals a surprisingly high number of driver mutations as well as genetic and epigenetic explanations for immune evasion by the tumor.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/134/26/2369/1549702/bloodbld2019002067.pdf

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