Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer’s Disease-Reference-Cited by-同舟云学术

Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer’s Disease

Published:2023-11-07 Issue:2 Volume:96 Page:499-505
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Ukraintseva Svetlana¹,Duan Matt¹,Simanek Amanda M.²,Holmes Rachel¹,Bagley Olivia¹,Rajendrakumar Aravind L.¹,Yashkin Arseniy P.¹,Akushevich Igor¹,Tropsha Alexander³,Whitson Heather⁴,Yashin Anatoliy¹,Arbeev Konstantin¹

Affiliation:

1. Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA

2. Department of Foundational Sciences and Humanities, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA

3. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

4. Center for Aging and Human Development, Duke University Medical Center, Durham, NC, USA

Abstract

Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer’s disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65–75 with AD onset at age 75 or older, taking into account rs6859 polymorphism in NECTIN2 gene (AD risk factor). Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associated with lower odds of AD in carriers of rs6859 A allele, but not in non-carriers. We conclude that pneumococcal polysaccharide vaccine is a promising candidate for genotype-tailored AD prevention.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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