Associations Between Brainstem Volume and Alzheimer’s Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study

Author:

Jacobs Heidi I.L.1234,O’Donnell Adrienne56,Satizabal Claudia L.678,Lois Cristina124,Kojis Daniel56,Hanseeuw Bernard J.149,Thibault Emma14,Sanchez Justin S.14,Buckley Rachel F.1210,Yang Qiong5,DeCarli Charles11,Killiany Ron7,Sargurupremraj Muralidharan8,Sperling Reisa A.1212,Johnson Keith A.12412,Beiser Alexa S.567,Seshadri Sudha678

Affiliation:

1. Massachusetts General Hospital, Boston, MA, USA

2. Harvard Medical School, Boston, MA, USA

3. School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, Netherlands

4. Gordon Center for Medical Imaging, Boston, MA, USA

5. Boston University School of Public Health, Boston, MA, USA

6. The Framingham Heart Study, Framingham, MA, USA

7. Boston University School of Medicine, Boston, MA, USA

8. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA

9. Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

10. Melbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia

11. University of California, Davis, Davis, CA, USA

12. Brigham and Women’s Hospital, Boston, MA, USA

Abstract

The brainstem is among the first regions to accumulate Alzheimer’s disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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