Affiliation:
1. Medicinal and Natural Product Laboratory, Department of Chemistry, Chandigarh University, Gharuan, Mohali, Punjab, India
2. Department of Chemistry, Multani Mal Modi College, Patiala, Punjab, India
Abstract
Formazans are well-known complexing agents and form highly stable complexes with verity of metals that are useful for number of pharmaceutical applications. The activity profile of formazans and their complexes are huge that include antibacterial, antifungal, antioxidant, anti-fertility, anti-tubercular, antiviral, anti-inflammatory, anticancer, anti-HIV, and anti-proliferative are among the biological activities covered by the formazans. The structures, synthesis, reactions, and spectral properties of formazans have been studied to highlight their potential applications in a variety of bioactive phenomena and analytical applications. The biological potential of the compounds will be greatly enhanced when substitution is carried out at R and R2. We observed that electron withdrawing groups at para position (if R, R1 & R2 = phenyl ring) are the best substitutions to achieve potent pharmacological activities.
Subject
Materials Chemistry,Inorganic Chemistry,Organic Chemistry
Reference113 articles.
1. Synthesis and Characterization of New Trimethoprim-Formazan Derivatives with Studying Them against Breast Cancer Cells;Hussein Mejbel Azeez;Int J Biochem Biomol [Internet],2021
2. Chemistry of formazan;Al-araji;Int J Res Pharm Chem [Internet],2015
3. Ueber die Einwirkung von Diazobenzol auf Malonsäure;Pechmann;Berichte derDtsch Chem Gesellschaft,1892
4. Ueber die Einwirkung von Diazobenzol auf Nitromethan;Bamberger;Berichte derDtsch Chem Gesellschaft [Internet],1894
5. The chemistry of formazans and tetrazolium salts;Nineham;Chem Rev,1955