The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development

Author:

Peng Ruiting1,Huang Yun1,Huang Ping1,Liu Linyi2,Cheng Lei3,Peng Xian4

Affiliation:

1. Department of Stomatology, The General Hospital of Western Theater Command PLA, Chengdu, China

2. Maine Health Institute for Research, Scarborough, ME, USA

3. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontic, West China Hospital of Stomatology, Sichuan University, Chengdu, China

4. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China

Abstract

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that plays a vital role in regulating cell growth, differentiation and survival in various tissues. It participates in a variety of cellular processes, including cell apoptosis, cell migration and evasion, and plays a paradoxical role in tumor genesis and development. In the early stage of tumor, TGF-β inhibits the occurrence of tumor by inhibiting cell proliferation and regulating cell apoptosis. In the advanced stage of tumor, TGF-β promotes tumor development and affects prognosis by promoting cell survival and proliferation, cell migration and invasion, participates in immune escape, etc. In this article, we will review the paradoxical role of TGF-β on the occurrence and development of oral squamous cell carcinoma.

Publisher

IOS Press

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