Rapid Voluntary Blinking as a Clinical Marker of Parkinson’s Disease-Reference-Cited by-同舟云学术

Rapid Voluntary Blinking as a Clinical Marker of Parkinson’s Disease

Published:2024-07-23 Issue:5 Volume:14 Page:993-997
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Francis Michaela¹²,Zirra Alexandra¹³,Haque Tahrina³,Gallagher David³,Budu Caroline³,Lees Andrew J.⁴,Schrag Anette⁵,Noyce Alastair J.¹,Simonet Cristina¹

Affiliation:

1. Centre for Preventive Neurology, Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

2. Portsmouth Hospital University Trust, Portsmouth, UK

3. The Royal London Hospital, Barts Health NHS Trust, London, UK

4. Reta Lila Weston Institute of Neurological Studies, University College London Queen Square Institute of Neurology, London, UK

5. Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, London, UK

Abstract

Reduced spontaneous blinking is a recognized Parkinson’s disease (PD) feature. In contrast, voluntary blinking has been less studied and might serve as a measurable marker of facial bradykinesia. We tested 31 PD patients and 31 controls. Participants were filmed during conversation and a rapid blinking task. Both tasks were videorecorded to count the number of blinks per second. PD patients had lower blink rates. Rapid blinking accurately discriminated between groups with 77% sensitivity and 71% specificity. To conclude, rapid blinking may be a simple and quantifiable task of facial bradykinesia.

Publisher

IOS Press

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