Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease-Reference-Cited by-同舟云学术

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease

Published:2021-06-03 Issue:1 Volume:5 Page:443-468
ISSN:2542-4823
Container-title:Journal of Alzheimer's Disease Reports
language:
Short-container-title:ADR

Author:

Fowler Christopher¹,Rainey-Smith Stephanie R.²³⁴⁵,Bird Sabine²³,Bomke Julia⁶,Bourgeat Pierrick⁶,Brown Belinda M.³⁴,Burnham Samantha C.⁶,Bush Ashley I.¹,Chadunow Carolyn¹,Collins Steven¹,Doecke James⁶⁷,Doré Vincent⁶⁸,Ellis Kathryn A.¹⁹¹⁰,Evered Lis¹¹,Fazlollahi Amir⁶,Fripp Jurgen⁶,Gardener Samantha L.²³,Gibson Simon⁶,Grenfell Robert⁶,Harrison Elise¹,Head Richard⁶,Jin Liang¹,Kamer Adrian¹,Lamb Fiona⁸,Lautenschlager Nicola T.⁹,Laws Simon M.¹²¹³,Li Qiao-Xin¹,Lim Lucy²³,Lim Yen Ying¹¹⁴,Louey Andrea¹,Macaulay S. Lance⁶,Mackintosh Lucy¹,Martins Ralph N.²³¹⁵,Maruff Paul¹⁶,Masters Colin L.¹,McBride Simon⁶,Milicic Lidija¹²,Peretti Madeline¹²,Pertile Kelly¹,Porter Tenielle¹²¹³,Radler Morgan¹,Rembach Alan¹,Robertson Joanne¹,Rodrigues Mark²³,Rowe Christopher C.⁸³,Rumble Rebecca¹,Salvado Olivier¹⁷,Savage Greg¹⁸,Silbert Brendan¹¹,Soh Magdalene²³,Sohrabi Hamid R.³⁴¹⁵,Taddei Kevin²³,Taddei Tania²³,Thai Christine¹,Trounson Brett¹,Tyrrell Regan⁸,Vacher Michael⁶,Varghese Shiji¹,Villemagne Victor L.⁸¹⁹,Weinborn Michael²³⁵,Woodward Michael²⁰,Xia Ying⁶,Ames David¹⁹²¹,

Affiliation:

1. The Florey Institute, The University of Melbourne, Parkville, VIC, Australia

2. Centre of Excellence for Alzheimer’s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia

3. Australian Alzheimer’s Research Foundation (Ralph and Patricia Sarich Neuroscience Research Institute), Nedlands, WA, Australia

4. Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia

5. School of Psychological Science, University of Western Australia, Crawley, WA, Australia

6. Australian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia

7. Cooperative Research Council for Mental Health, Melbourne, VIC, Australia

8. Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia

9. University of Melbourne Academic Unit for Psychiatry of Old Age, Parkville, VIC, Australia

10. Melbourne School of Psychological Sciences, Melbourne, VIC, Australia

11. Department of Anaesthesia and Acute Pain Medicine, St Vincent’s Hospital Melbourne, Victoria Parade, Fitzroy, VIC, Australia

12. Collaborative Genomics and Translation Group, Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia

13. School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia

14. Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia

15. Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia

16. Cogstate Limited, Melbourne, VIC, Australia

17. CSIRO Data61, Brisbane, QLD, Australia

18. Department of Psychology, Macquarie University, Sydney, NSW, Australia

19. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

20. Department of Geriatric Medicine Austin Hospital, Heidelberg, VIC, Australia

21. National Ageing Research Institute (NARI), Parkville, VIC, Australia

Abstract

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s disease dementia (AD)) as an ‘Inception cohort’ who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an ‘Enrichment cohort’ (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations. Results: AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression. Conclusion: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Neuroscience

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