Affiliation:
1. Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Xin Song Jiang Road, Shanghai, China
Abstract
OBJECTIVE: To evaluate and optimize the additional diagnostic value of Doppler imaging for malignant NMLs detected by US. MATERIALS AND METHODS: The characteristics of 233 NMLs in Doppler imaging were analyzed, and different Adler grades of intralesional vessels were selected as the diagnostic cutoffs on Doppler imaging: grade 1 in the full cohort and in women < 40 years, and grade 0 in women ≥40 years. The diagnostic performance of US and US + Doppler imaging were calculated and compared with that of mammography. RESULTS: The AUC of US + Doppler was larger than that of US alone in each group (P < 0.001). In the full cohort, addition of Doppler imaging increased specificity of US, but decreased sensitivity. However, by use of different diagnostic cutoffs in the two subgroups, it was possible to achieve high sensitivity and specificity simultaneously, which were 100% and 75.8% in women < 40 years, 94.7% and 69.5% in women ≥40 years, respectively. The AUC + Doppler was comparable to that of mammography in the full cohort and in women ≥40 years. In women < 40 years, the AUC of the combination was larger than that of mammography (P < 0.001). CONCLUSION: Doppler imaging, with different Adler grades used as cutoffs in older versus younger women, can improve the specificity of US for the diagnosis of malignant NMLs without losing sensitivity. In younger women, US + Doppler imaging may be better than mammography.
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Hematology,Physiology
Reference39 articles.
1. Effect of mammographic screening from age 40 years on breast cancer mortality (UK Age trial): final results of a randomised, controlled trial;Duffy;Lancet Oncol,2020
2. Screening for Breast Cancer;Niell;Radiol Clin North Am,2017
3. Effectiveness of breast cancer screening: systematic review and meta-analysis to update the 2009 U.S. Preventive Services Task Force recommendation;Nelso;Ann Intern Med,2016
4. Ultrasound as the primary screening test for breast cancer: analysis from ACRIN 6666;Berg;J Natl Cancer Inst,2015
5. ACR BI-RADS(R) ultrasound. In: American College of Radiology. ACR BI-RADS(R) atlas, breast imaging reporting and data system;Mendelson;Reston:American College of Radiology,2013
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