The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

Author:

Bhat Ratan V.1,Andersson Ulf2,Andersson Shalini3,Knerr Laurent4,Bauer Udo1,Sundgren-Andersson Anna K.5

Affiliation:

1. Strategy and External Innovation, Cardiovascular, Renal and Metabolism Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Gothenburg, Sweden

2. Drug Safety and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Gothenburg, Sweden

3. Drug Metabolism and Pharmacokinetics, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Gothenburg, Sweden

4. Medicinal Chemistry Cardiovascular and Metabolic Disease, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D, Gothenburg, Sweden

5. Cardiovascular, Renal and Metabolic disease, Global Medicines Development, AstraZeneca Gaithersburg, MD, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

Reference49 articles.

1. 2012 Alzheimer’s disease facts and figures;Alzheimer’s Association;Alzheimers Dement,2012

2. Alzheimer’s disease;Blennow;Lancet,2006

3. The parahippocampal gyrus in Alzheimer’s disease. Clinical and preclinical neuroanatomical correlates;Van Hoesen;Ann N Y Acad Sci,2000

4. Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors;Avila;Expert Rev Neurother,2010

5. GSK-3β, a pivotal kinase in Alzheimer disease;Llorens-Martin;Front Mol Neurosci,2014

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