Affiliation:
1. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
Abstract
Akada et al. conducted a nationwide database study on patients with Alzheimer’s disease, examining risk factors and outcomes over 3 years. A significant association emerged between decreased daily activities and hip fractures. However, the odds ratio was 1.95 (with p = 0.020) may be inaccurate in men, considering the wide 95% confidence interval (1.12–3.51). Possible influencing factors include an inappropriate outcome variable, sparse-data bias, collinear covariates, and comorbidities. Moreover, exact propensity-score matching would be more efficient than nested matching. Limitations include potential recall bias in measuring daily activities and limited applicability of cause-effect relationships in a national database study.
Subject
Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience
Reference8 articles.
1. Nationwide database analysis of risk factors associated with decreased activities of daily living in patients with Alzheimer’s disease;Akada;J Alzheimers Dis,2023
2. Sparse data bias: A problem hiding in plain sight;Greenland;BMJ,2016
3. Penalization, bias reduction, and default priors in logistic and related categorical and survival regressions.;Greenland;Stat Med,2015
4. Dealing with the problem of monotone likelihood in the inflation of estimated effects in clinical studies. Comment on Hasegawa et al. Impact of blood type O on mortality of sepsis patients: A multicenter retrospective observational study;Tzeng;Diagnostics 2020,10, 826.,2022
5. Ultrasound guidance for central venous catheterisation. A Colombian national survey.;Calvache;Int J Qual Health Care,2018
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