Author:
Blakytny Robert,Brunner Georg
Abstract
SummaryThe transforming growth factor-β (TGF-β) family of growth factors are major regulators of wound repair, scar formation, and fibrosis. One of the prominent features of TGF-β biology is the fact that this growth factor is secreted as a latent precursor, which may be directed to and stored at specific sites in the cellular microenvironment. Targeting and mobilization, and particularly extracellular activation of latent TGF-β control the biological action of this growth factor. This review will focus on mechanisms of extracellular TGF-β regulation relevant to and potentially operating in wound repair and scarring.
Funder
Deutsche Forschungsgemeinschaft
Cited by
60 articles.
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