Affiliation:
1. The Department of Clinical Biochemistry, Herlev Hospital
2. The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark
3. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Abstract
BACKGROUND
Tobacco smoke chemicals may influence vitamin D metabolism and function, and conversely vitamin D may modify the carcinogenicity of tobacco smoke chemicals. We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population.
METHODS
A prospective population-based cohort of 9791 individuals from the Copenhagen City Heart Study who were free of cancer at baseline was followed from 1981–1983 until December 2008 with 100% complete follow-up.
RESULTS
During up to 28 years of follow-up, 1081 participants developed a tobacco-related cancer and 1506 developed other cancers. Decreasing 25(OH)D concentrations, subdivided by clinical categories or by seasonally adjusted percentile categories, were associated with increasing cumulative incidence of tobacco-related cancer (log-rank trend P = 2 × 10−6 and P = 5 × 10−9). Multivariable adjusted hazard ratios of tobacco-related cancer were 1.75 (95% CI, 1.33–2.30) for 25(OH)D <5 vs ≥20 ng/mL, and 2.07 (1.63–2.62) for ≤5th vs >66th percentile. Also, multivariable adjusted hazard ratios for a 50% reduction in 25(OH)D were 1.20 (1.13–1.28) for any tobacco-related cancer, 1.19 (95% CI, 1.09–1.31) for lung cancer, 1.44 (1.19–1.73) for head and neck cancer, 1.28 (1.06–1.54) for bladder cancer, 1.34 (1.04–1.73) for kidney cancer, and 0.95 (0.89–1.01) for other cancers.
CONCLUSIONS
Lower plasma 25(OH)D was associated with higher risk of tobacco-related cancers, but not with risk of other cancers.
Funder
Danish Heart Foundation
Herlev Hospital
Copenhagen University Hospital
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Reference40 articles.
1. Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3;Eisman;Cancer Res,1987
2. 1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo;Mantell;Circ Res,2000
3. 1 alpha,25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer;Nakagawa;Carcinogenesis,2005
4. 22-Oxa-1alpha,25-dihydroxyvitamin D3 inhibits metastasis and angiogenesis in lung cancer;Nakagawa;Carcinogenesis,2005
5. 1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells;Simboli-Campbell;J Steroid Biochem Mol Biol,1996
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