Treatment of Metastatic Renal Cell Carcinoma With Autologous T-Lymphocytes Genetically Retargeted Against Carbonic Anhydrase IX: First Clinical Experience

Author:

Lamers Cor H.J.1,Sleijfer Stefan1,Vulto Arnold G.1,Kruit Wim H.J.1,Kliffen Mike1,Debets Reno1,Gratama Jan W.1,Stoter Gerrit1,Oosterwijk Egbert2

Affiliation:

1. Departments of Medical Oncology, Pharmacy, and Pathology, Erasmus University Medical Center–Daniel den Hoed Cancer Center, Rotterdam, the Netherlands

2. Department of Experimental Urology, University Medical Center, Nijmegen, the Netherlands

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Reference11 articles.

1. Weijtens MEM, Willemsen RA, Valerio D, et al: Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity. J Immunol 157:836,1996-843,

2. Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer

3. Lamers CHJ, Willemsen RA, van Elzakker P, et al: Phoenix-ampho outperforms PG13 as retroviral packaging cells to transduce human T cells with tumor-specific receptors: Implications for clinical immunogene therapy of cancer. Cancer Gene Ther 10.1038/sj.cgt.7700916 (Epub ahead of print on November 11, 2005)

4. Parallel Detection of Transduced T Lymphocytes After Immunogene Therapy of Renal Cell Cancer by Flow Cytometry and Real-Time Polymerase Chain Reaction: Implications for Loss of Transgene Expression

5. Divgi CR, O'Donoghue JA, Welt S, et al: Phase I clinical trial with fractionated radioimmunotherapy using 131I-labeled chimeric G250 in metastatic renal cancer. J Nucl Med 45:1412,2004-1421,

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