Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994-Reference-Cited by-同舟云学术

Randomized Phase III Study Comparing Neoadjuvant Chemotherapy Followed by Surgery Versus Chemoradiation in Stage IB2-IIB Cervical Cancer: EORTC-55994

Published:2023-11-10 Issue:32 Volume:41 Page:5035-5043
ISSN:0732-183X
Container-title:Journal of Clinical Oncology
language:en
Short-container-title:JCO

Author:

Kenter Gemma G.¹^ORCID,Greggi Stefano²,Vergote Ignace³^ORCID,Katsaros Dionyssios⁴,Kobierski Juliusz⁵,van Doorn Heleen⁶^ORCID,Landoni Fabio⁷,van der Velden Jacobus⁸^ORCID,Reed Nicholas⁹,Coens Corneel¹⁰,van Luijk Iske¹¹,Colombo Nicoletta¹²^ORCID,Steen-Banasik Elzbietta van der¹³,Ottevanger Nelleke¹⁴^ORCID,Casado Antonio¹⁵,Schratter-Sehn Annemarie,Vergote Ignace,Vermorken Jan Baptist,Altintas Sevilay,Kridelka Frederic,Goffin Frédéric,Joly-Lobbedez Florence,Katsaros Dionyssios,Greggi Stefano,Colombo Nicoletta,Landoni Fabio,Zola Paolo,Ferrero Annamaria,Franchi Massimo,Donadello Nicoletta,Massuger Leon,Ansink Anca,Van Doorn Helena,Van Der Velden Jacobus,Verheijen Rene,van Baal W.M.,Kenter Gemma,Van Dorst Eleonora,Kenter Gemma,Gaarenstroom Katja,Kristensen Gunnar,Kobierska Anna,Kobierski Julisz,de Oliveira Carlos Freire,Frutuoso Cristina,Casado Herraez Antonio,Reed Nicholas,Jyothirmayi Rema,Nordin Andrew,Rustin Gordon,

Affiliation:

1. Center for Gynaecologic Oncology Amsterdam, Amsterdam University Medical Center, Netherlands Cancer Institute, Amsterdam, the Netherlands

2. Gynaecologic Oncology, Istituto Nazionale Tumori di Napoli IRCCS “Fondazione G. Pascale”, Naples, Italy

3. Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

4. Department of Surgical Sciences, AOU Citta della Salute, Gynecologic Oncology, PO SANNA, University of Torino, Torino, Italy

5. Department of Gynecology and Gynecologic Oncology, Medical University of Gdansk, Gdansk, Poland

6. ErasmusMC Cancer Institute, University Medical Center, Rotterdam, the Netherlands

7. Gynecologic Clinic Milano Bicocca University, Ospedale San Gerardo, Monza, Italy

8. Amsterdam University Medical Center, Amsterdam, the Netherlands

9. Medical Oncology, Gartnavel General Hospital, Glasgow, United Kingdom

10. European Organization on Research and Treatment of Cancer Headquarters, Brussels, Belgium

11. Haaglanden Medical Center, The Hague, the Netherlands

12. European Institute of Oncology, Milano, Italy

13. Radiotherapiegroep Arnhem, Amsterdam, the Netherlands

14. Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands

15. Medical Oncology, University Hospital San Carlos, Madrid, Spain

Abstract

The EORTC-55994 trial compared neoadjuvant chemotherapy (NACT) followed by radical surgery with concomitant chemoradiation (CCRT) in patients with Stage IB2-IIB cervical cancer. This trial took almost 12 years to recruit 626 patients with a median follow-up of 8.7 years.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Link

https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.02852

Reference20 articles.

1. Global cancer statistics

2. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis

3. Neoadjuvant chemotherapy in cervical carcinoma stage IIB: a randomized controlled trial

4. Neoadjuvant Chemotherapy and Radical Surgery Versus Exclusive Radiotherapy in Locally Advanced Squamous Cell Cervical Cancer: Results From the Italian Multicenter Randomized Study

5. New Standard of Care for Cervical Cancer Sets Stage For Next Questions

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