Advanced Epithelial Ovarian Cancer: Do More Options Mean Greater Benefits?

Author:

Bouberhan Sara1,Shea Meghan1,Cannistra Stephen A.1

Affiliation:

1. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

Abstract

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A healthy 51-year-old woman presented with increasing abdominal and pelvic pain. Computed tomography imaging of the abdomen and pelvis showed an 11.6-cm pelvic mass, retroperitoneal lymphadenopathy, right hydronephrosis, and mesenteric tumor deposits ( Fig 1A ). A serum CA-125 was elevated at 1,149 U/mL. She underwent primary surgical cytoreduction including hysterectomy, bilateral salpingo-oophorectomy, appendectomy, resection of pelvic tumor, omentectomy, and low anterior resection with colorectal anastomosis. Intraoperatively, she was noted to have bilateral ovarian masses, pelvic and para-aortic lymphadenopathy, and a 4-cm omental tumor; in addition, both the uterus and rectosigmoid colon had adherent tumor deposits. All gross tumor was resected during the procedure. Final pathology confirmed high-grade serous carcinoma of ovarian origin ( Fig 1B ) that was determined to be stage IIIC as a result of upper abdominal involvement with greater than 2-cm tumor deposits, as well as retroperitoneal lymph node involvement. She underwent germline genetic testing, which did not identify a mutation in the BRCA1, BRCA2, BRIP1, RAD51C, or RAD51D genes. She presented for adjuvant chemotherapy after an optimal (R0) resection.

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Identification of AK4 as a novel therapeutic target for serous ovarian cancer;Oncology Letters;2020-10-08

2. Immunology and ovarian cancers;Journal of the Chinese Medical Association;2020-05

3. Bleeding and bowel obstruction in giant ovarian serous carcinoma – a video vignette;Colorectal Disease;2020-02-06

4. Reply to R.J. Buckanovich et al;Journal of Clinical Oncology;2019-10-10

5. No Role for Maintenance Bevacizumab for Up-Front Stage IIIc (R0) Ovarian Cancer;Journal of Clinical Oncology;2019-10-10

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