Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum

Author:

Guo Yi12345,Zhang Na12345,Sun Weiguang12345,Duan Xueyan12345,Zhang Qing12345,Zhou Qun12345,Chen Chunmei12345,Zhu Hucheng12345,Luo Zengwei12345,Liu Junjun12345ORCID,Li Xiao-Nian678910,Xue Yongbo12345ORCID,Zhang Yonghui12345ORCID

Affiliation:

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation

2. School of Pharmacy

3. Tongji Medical College

4. Huazhong University of Science and Technology

5. Wuhan 430030

6. State Key Laboratory of Phytochemistry and Plant Resources in West China

7. Kunming Institute of Botany

8. Chinese Academy of Sciences

9. Kunming 650204

10. People's Republic of China

Abstract

Fifteen new polycyclic polyprenylated acylphloroglucinols with dual-targeted inhibitory activities for Alzheimer's disease, were isolated from Hypericum perforatum.

Funder

Ministry of Education of the People's Republic of China

National Natural Science Foundation of China

Huazhong University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference56 articles.

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3. Alzheimer's disease: strategies for disease modification

4. sym-Triazines for Directed Multitarget Modulation of Cholinesterases and Amyloid-β in Alzheimer’s Disease

5. Managing Cognitive Dysfunction through the Continuum of Alzheimerʼs Disease

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