Chimeric oligosaccharide conjugate induces opsonic antibodies against Streptococcus pneumoniae serotypes 19A and 19F-Reference-Cited by-同舟云学术

Chimeric oligosaccharide conjugate induces opsonic antibodies against Streptococcus pneumoniae serotypes 19A and 19F

Published:2020 Issue:28 Volume:11 Page:7401-7407
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sanapala Someswara Rao¹²³⁴,Seco Bruna M. S.¹²³⁴⁵,Baek Ju Yuel¹²³⁴,Awan Shahid I.¹²³⁴,Pereira Claney L.⁵⁶⁷⁴,Seeberger Peter H.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomolecular Systems

2. Max Planck Institute of Colloids and Interfaces

3. D-14424 Potsdam

4. Germany

5. Department of Chemistry and Biochemistry

6. Freie Universität Berlin

7. D-14195 Berlin

Abstract

Chimeric antigens are an attractive means to induce an immune response against multiple bacterial serotypes. The chimeric semisynthetic glycoconjugate ST19AF induced antibodies with opsonic activity able to kill ST19A and ST19F bacteria in rabbits.

Funder

Max-Planck-Gesellschaft

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02230F

Reference51 articles.

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5. Expansion and Evolution of Streptococcus pneumoniae Serotype 19A ST320 Clone as Compared to Its Ancestral Clone, Taiwan19F-14 (ST236)

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