Neuronal maturation-dependent nano–neuro interaction and modulation

Author:

Gupta Prashant1ORCID,Rathi Priya1,Gupta Rohit1,Baldi Harsh1,Coquerel Quentin2,Debnath Avishek1,Derami Hamed Gholami1,Raman Baranidharan2ORCID,Singamaneni Srikanth1ORCID

Affiliation:

1. Department of Mechanical Engineering and Materials Science, and Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA

2. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA

Abstract

We unveil that negative surface charge of nanoparticles renders selective nano–neuro interaction with a strong correlation between the maturation stage of individual neurons in the neural network and the density of nanoparticles bound on the neurons.

Funder

Air Force Office of Scientific Research

Washington University School of Medicine in St. Louis

Foundation for Barnes-Jewish Hospital

Office of Research Infrastructure Programs, National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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