Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases-Reference-Cited by-同舟云学术

Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases

Published:2015 Issue:18 Volume:13 Page:5279-5284
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Miller Duncan C.¹²³⁴⁵,Carbain Benoit¹²³⁴⁵,Beale Gary S.²⁶⁷⁵⁸,Alhasan Sari F.²⁶⁷⁵⁸,Reeves Helen L.²⁶⁷⁵⁸,Baisch Ulrich³⁴⁵⁸⁹^ORCID,Newell David R.²⁶⁷⁵⁸,Golding Bernard T.¹²³⁴⁵,Griffin Roger J.¹²³⁴⁵

Affiliation:

1. Newcastle Cancer Centre

2. Northern Institute for Cancer Research

3. School of Chemistry

4. Bedson Building

5. Newcastle University

6. Paul O'Gorman Building

7. Medical School

8. Newcastle upon Tyne

9. UK

Abstract

An improved synthesis from d-glucosamine of a purported Sulf-2 inhibitor is described, with assay data for this compound and analogues showing only weak inhibition of Sulf-2, and sulfatases ARSA or ARSB.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00211G

Reference26 articles.

1. Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans

2. Extracellular Sulfatases, Elements of the Wnt Signaling Pathway, Positively Regulate Growth and Tumorigenicity of Human Pancreatic Cancer Cells

3. Fibroblast growth factor signalling: from development to cancer

4. Wnt signalling and its impact on development and cancer

5. Glucosamine-6-sulfamate Analogues of Heparan Sulfate as Inhibitors of Endosulfatases

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 2D and 3D anticancer properties of C2-functionalised glucosamine-Pt (IV) prodrugs based on cisplatin scaffold;Frontiers in Chemistry;2024-05-06

2. Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2);Chemical Communications;2024

3. Para-Methoxybenzylidene Acetal-Protected D-Glucosamine Derivatives as pH-Responsive Gelators and Their Applications for Drug Delivery;Gels;2023-05-27

4. Catalyst-Controlled, Site-Selective Sulfamoylation of Carbohydrate Derivatives;Organic Letters;2022-06-22

5. Optimized and Scalable Synthesis of Carba‐α‐ d ‐Glucosamine;European Journal of Organic Chemistry;2020-11-04