Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair

Author:

Wu Shunli1234,Zhang Hao12,Wang Sicheng135,Sun Jinru123,Hu Yan126,Liu Han12,Liu Jinlong12,Chen Xiao7,Zhou Fengjin8,Bai Long12,Wang Xiuhui12ORCID,Su Jiacan12ORCID

Affiliation:

1. Institute of Translational Medicine, Shanghai University, Shanghai 200444, China

2. Organoid Research Center, Shanghai University, Shanghai, 200444, China

3. School of Medicine, Shanghai University, Shanghai 200444, China

4. School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

5. Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai, China

6. Shaoxing Institute of Technology at Shanghai University, Shaoxing, 312000, China

7. Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China

8. Department of Orthopaedics, Honghui Hospital, Xi’an Jiao Tong University, Xi’an 710000, China

Abstract

A novel strategy to prepare an in situ nanocomposite FLPKT hydrogel is proposed, in which ultrasound-triggered in situ gelation using ROS is a regulatory mechanism. Moreover, ROS generation and KGN release effectively improved cartilage regeneration.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3