Formal [4+1] cyclization of (thio/imido)hydrazides and ethyl 3,3,3-trifluoropropanoate: unified synthesis of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles-Reference-Cited by-同舟云学术

Formal [4+1] cyclization of (thio/imido)hydrazides and ethyl 3,3,3-trifluoropropanoate: unified synthesis of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles

Published:2022 Issue:43 Volume:46 Page:20755-20759
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zhao Lan¹²^ORCID,Xu Jun³,Ma Jun¹²,Yin Guangwei¹²,Li Fangyi¹²^ORCID,Suo Tongchuan¹²^ORCID,Wang Chunhua⁴^ORCID

Affiliation:

1. College of Pharmaceutical Engineering of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China

2. Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, P. R. China

3. School of Pharmaceutical Science & Technology, Tianjin University, Tianjin 300072, P. R. China

4. School of Medicine, Foshan University, Foshan 528225, P. R. China

Abstract

We have developed a unified approach to 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles with ethyl acetate decoration by treating hydrazides, thiohydrazides and imidohydrazide with ethyl 3,3,3-trifluoropropanoate in the presence of a suitable base.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ04147B

Reference38 articles.

1. A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds

2. 1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy

3. A Review: Discovering 1,3,4-oxadiazole and chalcone nucleus for cytotoxicity/EGFR inhibitory anticancer activity

4. Review of Synthesis of 1,3,4-Oxadiazole Derivatives

5. Updates on synthesis and biological activities of 1,3,4-oxadiazole: A review

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Anion-Driven C-F Bond Cleavage of Trifluoromethyl N -Aryl Hydrazones Toward the Assembly of N-Heterocycles;2024

2. Anion-Driven C–F Bond Activation of Trifluoromethyl N-Aryl Hydrazones: Application to the Synthesis of 1,3,4-Oxadiazoles;The Journal of Organic Chemistry;2023-10-20

3. Recent developments in the chemistry of 1H- and 4H-1,2,4-triazoles;Advances in Heterocyclic Chemistry;2023

4. Five-membered ring systems: with more than one N atom;Progress in Heterocyclic Chemistry;2023