Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

Author:

Li Tong123,Wang Dianwei123,Guo Zhaopei13,Lin Lin13,Meng Meng123,Liu Cong4,Hao Kai4,Pang Xuan123ORCID,Tian Huayu12435ORCID,Chen Xuesi123ORCID

Affiliation:

1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China

3. Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China

4. State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

5. Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, China

Abstract

A biodegradable COF was constructed to break in response to tumors, enhancing the therapeutic effect on tumors.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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