Antimicrobial peptide-conjugated phage-mimicking nanoparticles exhibit potent bactericidal action against Streptococcus pyogenes in murine wound infection models

Author:

Olesk Johanna1,Donahue Deborah2ORCID,Ross Jessica3,Sheehan Conor4,Bennett Zach1,Armknecht Kevin5,Kudary Carlie6,Hopf Juliane6,Ploplis Victoria A.2ORCID,Castellino Francis J.2ORCID,Lee Shaun W.3,Nallathamby Prakash D.16ORCID

Affiliation:

1. Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana, USA

2. W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA

3. Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA

4. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

5. Department of Pre-Professional Studies, University of Notre Dame, Notre Dame, Indiana, USA

6. Berthiaume Institute for Precision Health, University of Notre Dame, Notre Dame, Indiana, USA

Abstract

Modularly assembled, antimicrobial peptide capped phage-mimicking nanoparticles are highly biocompatible, rapidly bactericidal, and clear wound infections without the emergence of antibacterial resistance.

Funder

Indiana Clinical and Translational Sciences Institute

American Cancer Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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