In vitro and in vivo evaluation of Rapamycin-eluting nanofibers coated on cardia stents

Author:

Zhu Yueqi12345,Edmonds Laura123,Zhao Xin678910,Chen Xinliang123,Hu Changmin123,Cheng Yingsheng451112,Cui Wenguo1231314

Affiliation:

1. Orthopedic Institute

2. Soochow University

3. Suzhou, P.R. China

4. Department of Radiology

5. The Sixth Affiliated People's Hospital

6. Center for Biomedical Engineering

7. Department of Medicine

8. Brigham and Women's Hospital

9. Harvard Medical School

10. Cambridge, USA

11. Medical School of Shanghai Jiao Tong University

12. Shanghai, P.R. China

13. Department of Orthopedics

14. The First Affiliated Hospital of Soochow University

Abstract

Diagram of the process used to fabricate non-biodegradable metal stents with an outer layer of Rapa-loaded fibrous membrane using the electrospinning process. With the release of Rapa, the stents are expected to inhibit fibroblast proliferation and tissue hyperplasia, therefore treating a benign cardia stricture.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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