Garcimultiflins A–C, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of <i>Garcinia multiflora</i> as interleukin-1β and pyroptosis inhibitors-Reference-Cited by-全球学者库

Garcimultiflins A–C, unusual polycyclic polyprenylated acylphloroglucinols from the pericarps of Garcinia multiflora as interleukin-1β and pyroptosis inhibitors

Published:2023 Issue:17 Volume:10 Page:4311-4319
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Cao Jun¹,Chen Jiali¹,Du Rongrong²,Zhang Qingwen¹,Gan Lishe³,Zhang Peicheng²^ORCID,Lin Ligen¹^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao 999078, China

2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

3. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China

Abstract

Garcimultiflins A–C (1–3), three PPAPs with unusual skeletons, were isolated from the pericarps of Garcinia multiflora. Compound 2 blocks the secretion of IL-1β through suppressing the activation of NLRP3 inflammasome in THP-1 macrophages.

Funder

Special Project for Research and Development in Key areas of Guangdong Province

Fundo para o Desenvolvimento das Ciências e da Tecnologia

National Natural Science Foundation of China

Universidade de Macau

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00752A

Reference27 articles.

1. Research Progress of Polycyclic Polyprenylated Acylphloroglucinols

2. Polycyclic Polyprenylated Acylphloroglucinols

3. Hyperbenzones A and B, two 1,2-seco and rearranged polycyclic polyprenylated acylphloroglucinols from Hypericum beanii

4. Natural polyprenylated benzophenones inhibiting cysteine and serine proteases

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