The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs-Reference-Cited by-同舟云学术

The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs

Published:2024 Issue:9 Volume:5 Page:901-913
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Cioccolo Sara¹²,Barritt Joseph D.¹,Pollock Naomi³,Hall Zoe⁴,Babuta Julia⁴,Sridhar Pooja³,Just Alicia⁵,Morgner Nina⁵^ORCID,Dafforn Tim³,Gould Ian²^ORCID,Byrne Bernadette¹^ORCID

Affiliation:

1. Department of Life Sciences, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK

2. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, Shepherd's Bush, London W12 0BZ, UK

3. School of Biosciences, University of Birmingham, Birmingham, UK

4. Division of Systems Medicine, Imperial College London, London, UK

5. Institute of Physical and Theoretical Chemistry, J.W. Goethe-University, Frankfurt am Main, Germany

Abstract

MmpL3 is an essential mycobacterial transporter. Extensive biophysical analysis reveals for the first time that MmpL3 exists as a dimer in different membrane mimetics.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00110A

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