Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen

Author:

Zhao Rongrong1,Wen Simiaomiao1,Fu Hao1,Liu Mengna1,Liu Qixing1,Zhou Haifeng1ORCID

Affiliation:

1. Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China

Abstract

A simple, efficient and clean intramolecular oxidative dehydrogenative coupling for the synthesis of dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones, and analogues promoted by bis(2-methoxyethyl)ether/O2 has been achieved.

Funder

Natural Science Foundation of Hubei Province

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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