Late-stage peptide modification and macrocyclization enabled by tertiary amine catalyzed tryptophan allylation-Reference-Cited by-同舟云学术

Late-stage peptide modification and macrocyclization enabled by tertiary amine catalyzed tryptophan allylation

Published:2024 Issue:28 Volume:15 Page:11099-11107
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Yuyang¹²³,Li Guofeng³^ORCID,Ma Wen²,Bao Guangjun²,Li Yiping²,He Zeyuan²,Xu Zhaoqing²^ORCID,Wang Rui¹²³^ORCID,Sun Wangsheng¹²^ORCID

Affiliation:

1. Research Unit of Peptide Science (2019RU066), Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China

2. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

3. School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, China

Abstract

An unprecedented tertiary amine catalyzed peptide allylation between Trp and MBH carbonates was disclosed, to enable late-stage peptide functionalization and macrocyclization both in traditional homogeneous phase and on-resins in SPPS.

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01244E

Reference59 articles.

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Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tertiary Amine Catalyzed Late-Stage Tryptophan Allylation of Peptides;Synfacts;2024-08-16

2. Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts;Nature Communications;2024-08-12