Phenylarsine oxide (PAO) induces apoptosis in HepG2 cells<i>via</i>ROS-mediated mitochondria and ER-stress dependent signaling pathways-Reference-Cited by-同舟云学术

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Phenylarsine oxide (PAO) induces apoptosis in HepG2 cellsviaROS-mediated mitochondria and ER-stress dependent signaling pathways

Published:2017 Issue:12 Volume:9 Page:1756-1764
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Huang Ping¹²³⁴,Zhang Yu Hua⁵⁶⁴,Zheng Xiao Wei¹²³⁴,Liu Yu Jia¹²³⁴,Zhang Hong¹²³⁴,Fang Luo¹²³⁴,Zhang Yi Wen¹²³⁴,Yang Chang⁷⁸⁹³⁴,Islam Khairul¹⁰¹¹⁹³⁴,Wang Chao¹⁰¹¹⁹³⁴,Naranmandura Hua⁷⁸⁹³⁴^ORCID

Affiliation:

1. Department of Pharmacy

2. Zhejiang Cancer Hospital

3. Hangzhou

4. China

5. Zhejiang Provincial People's Hospital

6. Hangzhou 310014

7. Department of Pharmacology

8. School of Medicine

9. Zhejiang University

10. Department of Toxicology

11. School of Medicine and Public Health

Abstract

PAO showed potent cytotoxic effects on arsenic resistant human hepatocellular carcinoma HepG2 cells by producing ROS.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00179G

Reference37 articles.

1. Alcohol, cofactors and the genetics of hepatocellular carcinoma

2. Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region

3. Current systemic treatment of hepatocellular carcinoma: A review of the literature

4. Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells

5. TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH SINGLE-AGENT ARSENIC TRIOXIDE

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