High-throughput Raman spectroscopy allows ex vivo characterization of murine small intestinal intra-epithelial lymphocytes (IEL)

Author:

Guliev Rustam R.1ORCID,Vogler Tina23,Arend Natalie1,Eiserloh Simone14,Wiede Alexander1,Kunert Timo23,Dinkel Martin23,Popp Jürgen145,Schie Iwan W.16ORCID,Hildner Kai23,Neugebauer Ute145ORCID

Affiliation:

1. Leibniz Institute of Photonic Technology, 07745 Jena, Germany

2. University Hospital Erlangen, Medical Department 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany

3. Deutsches Zentrum Immuntherapie (DZI), University Hospital Erlangen, Erlangen, Germany

4. Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany

5. Friedrich Schiller University Jena, Institute of Physical Chemistry and Abbe Center of Photonics, 07743 Jena, Germany

6. University of Applied Sciences Jena, Department for Medical Engineering and Biotechnology, 07745 Jena, Germany

Abstract

Intestinal inflammation-driving T cells within the epithelial layer of the small intestine can be identified and further characterized by Raman spectroscopy ex vivo.

Funder

Leibniz-Gemeinschaft

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

H2020 Marie Skłodowska-Curie Actions

Freistaat Thüringen

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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