Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies-Reference-Cited by-同舟云学术

Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies

Published:2024 Issue:2 Volume:14 Page:1018-1033
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Saeed Aamer¹^ORCID,Ahmed Atteeque¹,Haider Main Bilal¹,Ismail Hammad²,Hayat Khizar³,Shabir Ghulam¹,El-Seedi Hesham R.⁴⁵

Affiliation:

1. Department of Chemistry, Quaid I Azam University, Islamabad, 45320, Pakistan

2. Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat, 50700, Pakistan

3. Department of Botany, University of Gujrat, Gujrat, 50700, Pakistan

4. International Research Centre for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China

5. Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia

Abstract

IC50 values of the new synthesized pyrazoline-acyl thioureas revealed 5b and 5g as potent urease inhibitors. Whilst compound 5b is a potent α-glucosidase inhibitor, compound 5f is a potent amylase inhibitor, compound 5b is a potent antioxidant.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA06812A

Reference40 articles.

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5. Hybrid Pharmacophoric Approach in the Design and Synthesis of Coumarin Linked Pyrazolinyl as Urease Inhibitors, Kinetic Mechanism and Molecular Docking