Effect of chondroitin sulfate modified polyethyleneimine on mediating oligodeoxynucleotide YW002 in the treatment of periodontitis

Author:

Qu Xingyuan12ORCID,Zhang Qian32,Zhang Chuang4,Sun Jichao5,Du Siyu12,Liang Chen12,Chen Yabing12,Zheng Yi1ORCID,Wang Lei1

Affiliation:

1. Department of Periodontology, Hospital of Stomatology, Jilin University, 1500 Tsinghua Road, Chaoyang District, Changchun 130021, China

2. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, 763 Heguang Road, Chaoyang District, Changchun 130021, China

3. Second Affiliated Hospital, Jinzhou Medical University, 49 Shanghai Road, Guta District, Jinzhou 121000, China

4. School of Pharmacy, Jilin Medical University, 5 Jilin Street, Jilin 132013, China

5. Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, China

Abstract

In a previous study, we found that oligodeoxynucleotide (ODN) YW002 could downregulate the synthesis of nitric oxide in RAW 264.7 cells, laying the experimental foundation for the subsequent application of ODN YW002 in periodontitis.

Funder

Education Department of Jilin Province

Department of Finance of Jilin Province

Publisher

Royal Society of Chemistry (RSC)

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