Protein scaffolds: antibody alternatives for cancer diagnosis and therapy-Reference-Cited by-同舟云学术

Protein scaffolds: antibody alternatives for cancer diagnosis and therapy

Published:2022 Issue:7 Volume:3 Page:830-847
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Luo Renli¹^ORCID,Liu Hongguang¹^ORCID,Cheng Zhen²³^ORCID

Affiliation:

1. Department of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang, China

2. State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

3. Drug Discovery Shandong Laboratory, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China

Abstract

Although antibodies are well developed and widely used in cancer therapy and diagnostic fields, some defects remain, such as poor tissue penetration, long in vivo metabolic retention, potential cytotoxicity, patent limitation, and high production cost.

Funder

Science and Technology Commission of Shanghai Municipality

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00094F

Reference218 articles.

1. Precision Oncology: The Road Ahead

2. Molecular profiling for precision cancer therapies