Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE)-Reference-Cited by-同舟云学术

Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE)

Published:2022 Issue:7 Volume:3 Page:916-930
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Frosi Yuri¹,Ng Simon¹,Lin Yen-Chu²,Jiang Shimin¹,Ramlan Siti Radhiah¹,Lama Dilraj³,Verma Chandra S.⁴^ORCID,Asial Ignacio⁵⁶,Brown Christopher J.¹^ORCID

Affiliation:

1. Disease Intervention Technology Lab (DITL), IMCB (A*STAR), 8A Biomedical Grove, #06-04/05, Neuros/Immunos, 138648, Singapore

2. Insilico Medicine Taiwan Ltd., Suite 2013, No. 333, Sec.1, Keelung Rd., Xinyi Dist. 110, Taipei, Taiwan

3. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Biomedicum Quarter 7B-C Solnavägen 9, 17165 Solna, Sweden

4. Bioinformatics Institute (A*STAR), 30 Biopolis Street, #07-01 Matrix, 138671, Singapore

5. DotBio, 1 Research Link, 117604, Singapore

6. Nanyang Technological University, School of Biological Sciences, Singapore

Abstract

Identifying new binding sites and poses that modify biological function are an important step towards drug discovery.

Funder

Agency for Science, Technology and Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00099G

Reference43 articles.

1. The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

2. Modulation of Protein–Protein Interactions for the Development of Novel Therapeutics

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4. Flexibility and small pockets at protein–protein interfaces: New insights into druggability

5. Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions

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