Expansion of chemical space for natural products by uncommon P450 reactions
Author:
Affiliation:
1. Shandong Provincial Key Laboratory of Synthetic Biology
2. CAS Key Laboratory of Biofuels at Qingdao Institute of Bioenergy and Bioprocess Technology
3. Chinese Academy of Sciences
4. Qingdao
5. China
Abstract
This review focuses on unusual P450 reactions related to new chemistry, skeleton construction, structure re-shaping, and protein–protein interactions in natural product biosynthesis, which play significant roles in chemical space expansion for natural products.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/NP/C7NP00028F
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