Development of 1,3-acetonedicarboxylate-derived glucoside amphiphiles (ACAs) for membrane protein study

Author:

Lee Ho Jin1ORCID,Ehsan Muhammad1,Zhang Xiang2,Katsube Satoshi3ORCID,Munk Chastine F.4,Wang Haoqing5,Ahmed Waqar1,Kumar Ashwani1ORCID,Byrne Bernadette6ORCID,Loland Claus J.4ORCID,Guan Lan3,Liu Xiangyu2,Chae Pil Seok1ORCID

Affiliation:

1. Department of Bionano Engineering, Hanyang University, Ansan 155-88, Korea

2. Beijing Advanced Innovation Center for Structural Biology, School of Medicine, School of Pharmaceutical Sciences, Tsinghua University, 100084 Beijing, China

3. Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

4. Department of Neuroscience, University of Copenhagen, Copenhagen, DK-2200, Denmark

5. Department of Molecular and Cellular Physiology, Stanford University, California 94305, USA

6. Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK

Abstract

Newly developed amphiphiles, designated ACAs, are not only efficient at extracting G protein-coupled receptors from the membranes, but also conferred enhanced stability to the receptors compared to the gold standards (DDM and LMNG).

Funder

National Institutes of Health

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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