Thermosensitive chitosan-based hydrogels supporting motor neuron-like NSC-34 cell differentiation

Author:

Stanzione Antonella12,Polini Alessandro2,La Pesa Velia3,Quattrini Angelo3,Romano Alessandro3,Gigli Giuseppe12,Moroni Lorenzo24ORCID,Gervaso Francesca2ORCID

Affiliation:

1. Dipartimento di Matematica e Fisica E. De Giorgi, University of Salento, 73100 Lecce, LE, Italy

2. CNR-Nanotec, Institute of Nanotechnology, 73100 Lecce, Italy

3. IRCCS San Raffaele Scientific Institute, Neuropathology Unit, Institute of Experimental Neurology and Division of Neuroscience, 20132 Milan, Italy

4. Complex Tissue Regeneration department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER Maastricht, The Netherlands

Abstract

A new drop-by-drop method was developed to prepare a thermosensitive, chitosan-based hydrogel system that allowed easy encapsulation of NSC-34 cells, supporting their viability and favouring their differentiation.

Funder

Regione Puglia

Ministero dell’Istruzione, dell’Università e della Ricerca

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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