Cisplatin nanoparticles boost abscopal effect of radiation plus anti-PD1 therapy-Reference-Cited by-同舟云学术

Cisplatin nanoparticles boost abscopal effect of radiation plus anti-PD1 therapy

Published:2021 Issue:8 Volume:9 Page:3019-3027
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wang Ying¹²³⁴,Shen Na⁵⁶⁷⁸⁴,Wang Yue⁵⁶⁷⁸⁴,Li Mo¹²³⁴,Zhang Wanze⁹¹⁰¹¹¹²⁴,Fan Liwen¹²³⁴,Liu Linlin¹²³⁴,Tang Zhaohui⁵⁶⁷⁸⁴^ORCID,Chen Xuesi⁵⁶⁷⁸⁴^ORCID

Affiliation:

1. Department of Radiotherapy

2. The Second Hospital of Jilin University

3. Changchun 130041

4. PR China

5. Key Laboratory of Polymer Ecomaterials

6. Changchun Institute of Applied Chemistry

7. Chinese Academy of Sciences

8. Changchun 130022

9. Department of Pathogenobiology

10. College of Basic Medical Science

11. Jilin University

12. Changchun 130021

Abstract

CDDP-NPs amplify RT-induced ICD to prime CD8⁺ T cells and increase their infiltration into non-irradiated tumors by enhancing CXCL10 secretion, eventually augmenting the abscopal effect of RT plus anti-PD1.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00112D

Reference40 articles.

1. Whole Body Irradiation—Radiobiology or Medicine?

2. Cancer metastases: challenges and opportunities

3. Time to abandon single-site irradiation for inducing abscopal effects

4. Systematic review of case reports on the abscopal effect

5. PD-1 Restrains Radiotherapy-Induced Abscopal Effect

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