Salicylaldehyde-derived piperazine-functionalized hydrazone ligand-based Pt(<scp>ii</scp>) complexes: inhibition of EZH2-dependent tumorigenesis in pancreatic ductal adenocarcinoma, synergism with PARP inhibitors and enhanced apoptosis-Reference-Cited by-同舟云学术

Salicylaldehyde-derived piperazine-functionalized hydrazone ligand-based Pt(ii) complexes: inhibition of EZH2-dependent tumorigenesis in pancreatic ductal adenocarcinoma, synergism with PARP inhibitors and enhanced apoptosis

Published:2024 Issue:33 Volume:53 Page:13871-13889
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Lv Zhimin¹,Ali Amjad²³,Zou Cheng¹,Wang Zerui¹,Ma Minglu¹,Cheng Na¹,Shad Man¹⁴,Hao Huifang¹⁴,Zhang Yongmin¹⁵^ORCID,Rahman Faiz-Ur¹^ORCID

Affiliation:

1. Inner Mongolia University Research Center for Glycochemistry of Characteristic Medicinal Resources, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, People's Republic of China

2. Institute of Integrative Biosciences, CECOS University of IT and Emerging Sciences, Peshawar, KPK, Pakistan

3. Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, People's Republic of China

4. School of Life Sciences, Inner Mongolia University, Hohhot 010021, People's Republic of China

5. Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, 75005 Paris, France

Abstract

Methyl piperazine functionalized Pt(ii) complexes with general formula L-PtCl were prepared, structurally characterized and studied for their in vitro mechanistic anticancer effect in pancreatic ductal adenocarcinoma cells.

Funder

Inner Mongolia University

Inner Mongolia Autonomous Region

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT01243G

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